Metabolism of Benzoic Acid in Normal and Irradiated Rats.

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Abstract
The isotope concentration of the urinary hippuric acid of starved irradiated or non-irradiated rats given benzoic acid-carboxyl-C4 is much less than the dilution expected from the conjugation of the injected labeled benzoic acid with inert carbon atoms of the glycyl residue. Evidence is presented that benzoic acid is a normally occuring metabolite in rats. The effect of X-irradiation on the ability of starved rats to conjugate benzoic acid-carboxyl-Cl4 was tested and no defect detected under the experimental conditions used.

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