Osteogenesis Induced by Bone Matrix is Inhibited by Inflammation
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Medical Devices, and Artificial Organs
- Vol. 14 (3-4) , 227-237
- https://doi.org/10.3109/10731198609117544
Abstract
This study was designed to examine the effect of inflammatory reaction elicited by percutaneous tube on bone induction. Inflammation was provked by different types of biomaterials. In order to evaluate incorporation of percutaneous tubes, bone matrix and subcutaneous tissue, demineralizing bone matrix was implanted in the subcutaneous tissue of rats and was exposed to interaction with inflammatory conditions. Inhibition to the induction of cartilage and bone by the inflammatory process could be clearly demonstrated. It is suggested that the low pH levels, typical to enzymes operative in inflammation are a direct cause for inhibition of chondro and osteogenesis. The process of calcification is characterized by the activation of enzymes in high pH levels.Keywords
This publication has 2 references indexed in Scilit:
- Collagenous bone matrix-induced endochondral ossification hemopoiesis.The Journal of cell biology, 1976
- Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent RatsProceedings of the National Academy of Sciences, 1972