Particle Size Design Using Computer Optimization Technique
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 17 (4) , 471-483
- https://doi.org/10.3109/03639049109044257
Abstract
The effect of binder solution (amount and composition) on the mean particle size and its distribution of granule was investigated by using a computer optimization technique. The granules were manufactured by two continuous processes, granulating and sizing using a high-speed mixer granulator and a hammer mill, respectively. The particle size distribution pattern of granules was markedly varied with the change in the amount and composition of the binder solution. The distribution pattern could be well expressed by the log-normal distribution model. For designing the optimal particle, a computer optimization technique was applied to the experimental results obtained in this study. The technique was found to be useful for searching the optimal formula in the practical scale.Keywords
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