GENETIC RESISTANCE TO MARROW TRANSPLANTATION AS A LEUKEMIA DEFENSE-MECHANISM

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 25  (1) , 1-3
Abstract
(C57 .times. AKR)F1 hybrid mice show genetic resistance to C57 parental bone marrow cells, but not to AKR parental bone marrow cells. (C3H .times. AKR)F1 hybrids show no genetic resistance to bone marrow transplantation from either parental strain. Transplantation of AKR lymphoma cells into lethally irradiated resistant (C57 .times. AKR)F1 and non-resistant (C3H .times. AKR)F1 hybrids produce lymphomatous spleen colonies in nonresistant hybrids but not in resistant hybrids. Resistant (C57 .times. AKR)F1 hybrids can recognize and reject AKR lymphoma cells, but not normal AKR bone marrow cells. A normal biological role of lymphoma surveillance is postulated for genetic resistance.

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