DNASE-I INHIBITIONS IN TUMORS OF DIFFERENT METASTASIZING CAPACITIES - A POSSIBLE INDEX OF INVASIVENESS
- 1 January 1983
- journal article
- research article
- Vol. 7 (1) , 39-44
Abstract
Tumor pairs, selected [lymphoma] on the basis of their different capacities to metastasize in vivo (SP73/AS and ASML [adenocarcinomas] from the rat, Eb/ESb [lymphoma] from the mouse), were assayed for their membrane, associated actin through the DNase inhibition assay. Provided inhibitions per cell are corrected for the influence of gross heterogeneities in size distributions, the more metastatic tumor cells have significantly higher DNase I inhibitions than their less invasive counterparts. This observation is rationalized by postulating a participation of these actin pools to a property critical for both normal recirculation and metastatic spreading. Arguments are presented which favor cell surface deformability as a possible candidate.This publication has 6 references indexed in Scilit:
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