Formation de noradrénaline dans le cerveau du rat après administration de (+)-erythro-3,4-dihydroxyphenylsérine

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Abstract
Fluorescence microscopy of rat brains after administration of (+)-erythro-DOPS has been studied. (+)-erythro-DOPS induced an increase of brain NE part of which was formed in the capillary walls. The slight diminution of this increase when (+)-erythro-DOPS was administered after inhibition of peripheral decarboxylase, might result from the algebraic sum of two inversely acting processes: suppression of NE synthesis in the capillary walls and enhancement of parenchymatous NE in some brain areas. (+)-erythro-DOPS enters different brain structures non specifically and NE is formed in DA and 5-HT systems, displacing the amines especially at the terminals; the NE formed by (+)-erythro-DOPS in NE systems should be rapidly catabolised. Possible pharmacological effects of (+)-erythro-DOPS administration involve consideration of the lack of topical specificity of NE formation; the displacement of 5-HT and DA; and the fact (+)-erythro-DOPS produces (+)-NE, and not naturally occurring NE.