Elimination of Ethanol as a Measure of the Hepatic Blood Flow in the Cat

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Abstract
Larsen, J. A.Elimination of ethanol as a measure of the hepatic blood flow in the cat. I. Experiments with single injection of ethanol. Acta physiol. scand. 1963.57. 201—208. — The elimination curve following a single injection of 0.25 g ethanol per kg weight was studied in 13 cats anesthetized with Nembutal. It was found that the elimination was constant down to arterial concentrations of 40—60 mg/l, the mean value being 103.1 mg/kg/h. Below these concentrations the extraction in the liver was almost complete and the amount metabolized in the liver was thus dependent on concentration and liver blood flow. After correction for the amount of ethanol eliminated outside the liver the hepatic blood flow was calculated from the elimination curve. A mean value of 34.3 ml/kg/min was found.
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