Uptake of Radioactive Zinc and Manganese in Damaged Rat Liver

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Abstract
Hepatic injury was induced in 31 female Holtzman rats by the subcutaneous injection of 0.5 ml C Cl4. An equal number of rats were given 0.5 ml NaCl as controls. Forty-eight hrs. later 0.2 [mu]c of Zn65 was injected subcutaneously in 38 rats and 0.2 [mu]c of Mn54 was given to the remaining 24 rats. Animals receiving Zn65 were sacrificed in equal groups at 1, 3 and 9 hrs. following isotope administration. All animals receiving Mn54 were sacrificed at 3 hrs. Weighed aliquots of tissue from blood, heart, kidney and liver were counted in a scintillation well and % uptake in controls and C Cl4 poisoned animals were compared. No difference in uptake in any organ was noted in the animals receiving Zn65. On the other hand, Mn54 uptake was significantly reduced in the livers of rats receiving C C14 (p<.02). It is postulated that the difference of the behavior of these 2 metals in liver damage may be related to their intracellular distribution patterns. Manganese is concentrated to the highest degree in mitochondria and microsomes, which showed the pronounced morphologic damage in our study, whereas zinc is principally found in the nuclei and cell walls which appeared intact with the acute C Cl4 poisoning.

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