Lactate concentrations distinguish between nucleoside neuropathy and HIV neuropathy

1 May 2003

journal article
research article
Published by Wolters Kluwer Health in AIDS

Vol. 17 (7) , 1094-1096
https://doi.org/10.1097/00002030-200305020-00024

Abstract

We prospectively assessed serum lactate and plasma HIV viral load in 20 patients with stavudine-related nucleoside neuropathy, 10 with HIV-related distal sensory polyneuropathy (DSPN), 20 receiving stavudine but without neuropathy and 23 not receiving stavudine and without neuropathy. Raised serum lactate levels discriminated between stavudine nucleoside neuropathy and DSPN with 90% sensitivity and 90% specificity (P = 0.001). DSPN occurred despite an undetectable viral load, making it a poor discriminator.

Keywords

This publication has 3 references indexed in Scilit:

Severity of HIV-associated neuropathy is associated with plasma HIV-1 RNA levels
AIDS, 2002
Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy
Neurology, 1999
HIV-1 peripheral neuropathy and combination antiretroviral therapy.
The Lancet, 1998