Immunocytochemical localization of ubiquitin at human neuromuscular junctions
- 1 June 1992
- journal article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 18 (3) , 232-236
- https://doi.org/10.1111/j.1365-2990.1992.tb00785.x
Abstract
Using several specific monoclonal and polyclonal antibodies, we found that ubiquitin is highly concentrated in the post‐synaptic domain of human neuromuscular junctions. The distribution and pattern of ubiquitin immunoreactivity is identical to the localization of bound a‐bungarotoxin, suggesting that ubiquitin may be involved in post‐translational modification or turnover of the acetylcholine receptor or other junctional proteins of the muscle fibre.Keywords
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