N-Pyrrolyl Derivative Acids Chromatography

Abstract
A determination is made on the effects of the variation of pH, methanol %, contents of tetrabutylammonium salts, ionic strength and counterion nature of the mobile phase quaternary ammonium salt, on the retention of a series of analgesics formed by N-pyrrolyl derivative acids through a column constituted by 10 μ irregular particles of octadecyl silica. The results obtained are applied to mixture separation of said acids.