Developmental Pattern of 3-Methylcholanthrene-Inducible Mutagenic Activation of N-2-Fluorenylacetamide, 2-Fluorenamine, and 2,4-Diaminoanisole in the Rabbit23

1 April 1980

journal article
research article
Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute

Vol. 64 (4) , 765-769
https://doi.org/10.1093/jnci/64.4.765

Abstract

The effects of 3-methylcholanthrene (MCA) on mutagenic activation of the carcinogenic arylamines N-2-fluorenylacetamide (FAA), 2-fluorenamine (FA), and 2,4-diaminoanisole (2,4-DAA) by liver homogenates were studied postnatally in Dutch rabbits. These effects were compared with the developmental profiles of cytochrome P₄₄₈ and aryl hydrocarbon hydroxylase (AHH) activity. Mutagenic activation of FA and 2,4-DAA was increased by MCA as early as 2 days after birth, whereas induction of FAA mutagenicity appeared 6 days after birth. Thereafter, induction of all three arylamines closely paralleled induction of cytochrome P₄₄₈, which was maintained into adulthood. In contrast, induction of AHH activity by MCA was highest at 2 days of age and decreased to control levels 20 days after birth.

Keywords

This publication has 1 reference indexed in Scilit:

Metabolic activation of 2,4-diaminoanisole, a hair-dye component—II. Role of cytochrome P-450 metabolism in irreversible binding in vitro
Biochemical Pharmacology, 1979