The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
- 1 July 2002
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 4 (7) , E177-E184
- https://doi.org/10.1038/ncb0702-e177
Abstract
The small GTPase Ran is a key regulator of nucleocytoplasmic transport during interphase. The asymmetric distribution of the GTP-bound form of Ran across the nuclear envelope — that is, large quantities in the nucleus compared with small quantities in the cytoplasm — determines the directionality of many nuclear transport processes. Recent findings that Ran also functions in spindle formation and nuclear envelope assembly during mitosis suggest that Ran has a general role in chromatin-centred processes. Ran functions in these events as a signal for chromosome position.Keywords
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