C1q Inhibition of the Interaction of Collagen with Human Platelets
Open Access
- 1 January 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 116 (1) , 162-163
- https://doi.org/10.4049/jimmunol.116.1.162
Abstract
Human C1q, isolated in pure state after affinity chromatography on IgG-Sepharose, inhibited collagen-induced aggregation and release of 14C-Serotonin from prelabeled human platelets. Platelet aggregation induced by ADP or thrombin was not inhibited by C1q. Also, the adherence of platelets to glass surfaces was significantly diminished by C1q. In contrast, aggregated C1q mimicked the effect of collagen in causing platelet aggregation and release of serotonin. It appears that monomeric C1q, which has structural similarities to collagen competes with collagen for specific sites on the platelet surface.This publication has 1 reference indexed in Scilit:
- ALTERATION OF THE RESPONSE OF PLATELETS TO SURFACE STIMULI BY PYRAZOLE COMPOUNDSThe Journal of Experimental Medicine, 1967