Immunisation by means of bacterial endotoxins

Abstract
In a former paper it was shown that the intra-cellular constituents of bacterial cells, bacterial endotoxins, possess a considerable capacity for increasing the opsonising action of the serum of healthy rabbits. In the present paper, the action of bacterial endotoxins in immunising against injections of the corresponding living organisms has been investigated. Smallman, in an investigation upon the active immunisation of experimental animals with typhoid cell juices,f found that the fresh fluid cell juice and also the dried juice immunised guinea-pigs against injections of living typhoid culture. The endotoxins were prepared in the manner described in the previous paper. Guinea-pigs were the experimental animals employed throughout. The results obtained are summarised in the following sections:

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