Cord insulin and C‐peptide—distribution in an unselected population

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Abstract
Objective To assess the distribution of cord blood insulin in an unselected population, and examine its relation to birthweight centiles.Setting District General Hospital in Nottinghamshire.Subjects 209 unselected singleton births.Mean Outcome Measure Cord blood insulin; cord blood C‐peptide; birthweight centiles.Results Hyperinsulinaemic babies (> 97th centile for cord insulin) were found at all birthweight centiles. 15% of high birthweight babies were hyperinsulinaemic. For low birthweight babies, the distribution of cord insulin/C‐peptide was skewed indicating a high number of low values. Hypoinsulinaemic babies were present up to the 50th centile for birthweight.Conclusions Abnormalities of fetal insulinisation may be found in babies of all birthweights.