DISTRIBUTION OF BOVID-HERPESVIRUS-2 IN CALVES INOCULATED INTRAVENOUSLY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (6) , 943-947
Abstract
The behavior of Bovid herpesvirus 2 in the skin, lymph nodes and nervous system of calves injected intravenously with the virus was studied. After a latent phase that lasted up to 40 h after inoculation, the virus produced a systemic infection which was characterized by primary localization of virus in the skin lymph nodes and nervous system. Between postinoculation days 7-12, the infection tended to persist in the skin only. The finding of intranuclear inclusions in the pyramidal cells of the cerebral cortex and in the neurons of the superior cervical and stellate ganglia supports the hypothesis that the virus might utilize the structures of the nervous system for its replicative cycle in the calf.

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