COOPERATIVE PHASE DYNAMICS IN COUPLED NEPHRONS

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Abstract
The individual functional unit of the kidney (the nephron) displays oscillations in its pressure and flow regulation at two different time scales: Relatively fast oscillations associated with the myogenic dynamics of the afferent arteriole, and slower oscillations related with a delay in the tubuloglomerular feedback. Neighboring nephrons interact via vascularly propagated signals. We study the appearance of various forms of coherent behavior in a model of two such interacting nephrons. Among the observed phenomena are in-phase and anti-phase synchronization of chaotic dynamics, multistability, and partial phase synchronization in which the nephrons attain a state of chaotic phase synchronization with respect to their slow dynamics, but the fast dynamics remains desynchronized.

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