Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein
Top Cited Papers
- 25 April 2003
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 300 (5619) , 636-640
- https://doi.org/10.1126/science.1082324
Abstract
Alpha-synuclein (α-syn) and tau polymerize into amyloid fibrils and form intraneuronal filamentous inclusions characteristic of neurodegenerative diseases. We demonstrate that α-syn induces fibrillization of tau and that coincubation of tau and α-syn synergistically promotes fibrillization of both proteins. The in vivo relevance of these findings is grounded in the co-occurrence of α-syn and tau filamentous amyloid inclusions in humans, in single transgenic mice that express A53T human α-syn in neurons, and in oligodendrocytes of bigenic mice that express wild-type human α-syn plus P301L mutant tau. This suggests that interactions between α-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases.Keywords
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