Eosinophilia. I. Eosinophilia in guinea-pigs mediated by passive anaphylaxis and by antigen-antibody complexes containing homologous IgG1a and IgG1b.

  • 1 June 1972
    • journal article
    • Vol. 22  (6) , 1087-98
Abstract
There was an eight- to eleven-fold increase in the number of eosinophils in the peritoneal cavity of guinea-pigs repeatedly sensitized and subsequently challenged by that route. Peripheral blood eosinophilia was less and inconsistent. There were fewer eosinophils in the peritoneal cavity of guinea-pigs challenged intraperitoneally but sensitized by other routes, than in animals both sensitized and challenged peritoneally. Thus eosinophils were attracted to sites of antigenic challenge in anaphylactically sensitized tissue, particularly when sensitization occurred in the same tissue. In tissues repeatedly injected with antigen, there was an increase of mononuclear cells preceding and greater than the number of eosinophils.