Synthesis of 21-Diazo-9α-fluoro-16α-methyl-21-deoxy-[1,2(n)-3H]prednisolone
- 1 January 1980
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 361 (1) , 953-958
- https://doi.org/10.1515/bchm2.1980.361.1.953
Abstract
The preparation of 21-diazo-9.alpha.-fluoro-16.alpha.-methyl-21-deoxy-[1,2(n)-3H]prednisolone is described. [1,2(n)-3H]Dexamethasone 26 Ci/mmol, was oxidized with cupric acetate/air to give the 21-aldehyde. Treatment of the aldehyde with hydroxylamine gave the corresponding 21-oxime which was reacted with chloroamine to give a 25-35% yield of 21-diazo-9.alpha.-fluoro-16.alpha.-methyl-21-[1,2(n)-3H]deoxyprednisolone with a specific activity of 25-26 Ci/mmol.This publication has 5 references indexed in Scilit:
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