Complement Levels in Mammals.

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Abstract
Complement levels were determined by a modification of Mayer''s sheep cell hemolysis method (J. Exp. Med. 84: 535. 1946) in humans, guinea pig, dog, Chinese hamster, rat (Long-Evans), rabbit, mouse (C3H) with the following, respective mean values and standard deviations: 39.2 [plus or minus] 4.1; 262. [plus or minus] 36.; 35.7 [plus or minus] 7.9; 40.6 [plus or minus] 7.7; 32.4 [plus or minus] 8.4; 8.8 [plus or minus] 1.7; 0.67 [plus or minus] 0.38. All species except the mouse gave a slope for the hemolytic curve of 0.2[plus or minus] .02; normal C3H mice gave slopes of 0.38, 0.43, 0.59, 0.81 on 4 different occasions. Titers were reproducible within at least 5%, constant for at least 2 months if sera stored in dry ice. Serial titers on normal humans done during 1 year were constant within 10%. Complement in mice may be measured by the same hemolytic system used for other species.
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