Event-Related Potential Changes in Groups at Increased Risk for Alzheimer Disease
Open Access
- 1 November 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 56 (11) , 1398-1403
- https://doi.org/10.1001/archneur.56.11.1398
Abstract
INDIVIDUALS WHO have a family history (FH) of Alzheimer disease (AD) or who carry the apolipoprotein E (APOE) ϵ4 allele (E4+) are at increased risk for AD.1-7 For blood relatives of patients with AD, the risk of developing the disease approaches 50% after the age of 85 years.1,2 The APOE ϵ4 allele is a major risk factor for both late-onset familial and sporadic AD.4-7 Greater APOE ϵ4 allele dose (carrying 2 ϵ4 alleles rather than 1) is associated with both increased risk and earlier disease onset.4,7Keywords
This publication has 13 references indexed in Scilit:
- Beck Depression Inventory.Published by American Psychological Association (APA) ,2000
- Cognitive and neurobiologic markers of early Alzheimer diseaseProceedings of the National Academy of Sciences, 1996
- Electric source localization of the auditory P300 agrees with magnetic source localizationElectroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 1995
- Anterior and posterior association cortex contributions to the somatosensory P300Journal of Neuroscience, 1991
- The intracranial topography of the P3 event-related potential elicited during auditory oddballElectroencephalography and Clinical Neurophysiology, 1990
- Longitudinal Study of Cerebral Metabolic Asymmetries and Associated Neuropsychological Patterns in Early Dementia of the Alzheimer TypeArchives of Neurology, 1990
- Cholinergic and serotonergic effects on the P3 potential and recent memoryJournal of Clinical and Experimental Neuropsychology, 1989
- Is the P300 component a manifestation of context updating?Behavioral and Brain Sciences, 1988
- Age-related changes in auditory event-related potentialsElectroencephalography and Clinical Neurophysiology, 1980
- Evoked-Potential Correlates of Stimulus UncertaintyScience, 1965