The Isolation of Erythropoiesis Regulatory Factors by an Electrofractionation Technique Combined with Selective Membrane Permeability

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Abstract
A urine concentrate from a patient with paroxysmal nocturnal hemoglobinuria contained four regulators of erythro-poiesis that could be isolated by an electro-fractionation technique combined with selective membrane permeability. An erythropoie-sis-stimulating factor (ESF) passed toward the anode through a membrane with a cutoff at a molecular weight of 30,000, but was retained by a membrane with a cutoff at 20,000, while another ESF was retained by a membrane with a cutoff at 50,000. An ESF-generating factor passed toward the cathode through a membrane with a cutoff at 50,000 but was retained by a membrane with a cutoff at 30,000.

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