Three Hypolipidemic Drugs Increase Hepatic Palmitoyl-Coenzyme A Oxidation in the Rat

5 August 1977

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 197 (4303) , 580-581
https://doi.org/10.1126/science.195342

Abstract

Male rats treated with clofibrate, tibric acid, or Wy-14,643 show an 11- to 18-fold increase in the capacity of their livers to oxidize palmitoyl-coenzyme A. This provides a plausible biochemical mechanism for the action of these hypolipidemic drugs in reducing lipid concentrations in the serum.

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