Metabolic Responses to Levodopa

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To the Editor: Although the article by Sirtori and his associates1 confirms the finding of Boyd et al. that growth hormone is released by single doses of levodopa in fasting patients,2 it lacks both the internal and the external consistency necessary for predicting iatrogenic acromegaly.Sirtori et al. predict only harm from evoked releases of growth hormone, ignoring spontaneous releases of roughly similar magnitude found normally during sleep.3 They appear to be predicting the effects of the variable doses required for treatment, on the basis of fixed, single morning doses given to fasting patients. Although not one of their base-line . . .

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