Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
- 1 March 1993
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 362 (6415) , 31-38
- https://doi.org/10.1038/362031a0
Abstract
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.Keywords
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