X-ray sensitivity and DNA synthesis in synchronous culture ofPlasmodium falciparum
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in Zeitschrift Fur Parasitenkunde-Parasitology Research
- Vol. 71 (2) , 213-218
- https://doi.org/10.1007/bf00926271
Abstract
The relationship between parasite development and sensitivity to irradiation with X-rays was investigated during a single synchronous cycle ofPlasmodium falciparum in culture. The sensitivity of the parasites to irradiation was closely correlated with the phases of DNA synthesis. Their sensitivity was greatest at the ring stage in development, but decreased at the trophozoite stage when DNA synthesis begins. Lowest sensitivity was found when DNA synthesis was most rapid as the parasites were transforming from late trophozoite to schizont forms. These findings suggest that DNA is the target of the lethal radiation damage in the parasites.This publication has 11 references indexed in Scilit:
- Synthesis of DNA during the asexual cycle of Plasmodium falciparum in cultureMolecular and Biochemical Parasitology, 1984
- Plasmodium falciparum: Attenuation by irradiationExperimental Parasitology, 1983
- Plasmodium berghei: Isolation and maintenance of an irradiation attenuated strain in the nude mouseExperimental Parasitology, 1982
- Synchronization of Plasmodium falciparum Erythrocytic Stages in CultureJournal of Parasitology, 1979
- Human Malaria Parasites in Continuous CultureScience, 1976
- Mutation induction and inactivation in mammalian cells exposed to ionising radiationNature, 1975
- Transient G1 arrest of S. cerevisiae cells of mating type α by a factor produced by cells of mating type aExperimental Cell Research, 1974
- Variations in Several Responses of HeLa Cells to X-Irradiation during the Division CycleBiophysical Journal, 1963