Effect of Drug Pretreatment on the Metabolic Oxidation of Chlorpromazine in Rat

Publisher Website
Google Scholar
Abstract
The metabolic oxidation of chlorpromazine (CPZ) was investigated after pretreatment of rats with some drugs and chemicals for 6 days. Pentobarbitone, γ-collidine, ethanol, and anthracene induced a significant increase in both S-oxidation and 7-hydroxylation, whereas CPZ pretreatment increased mainly 7-hydroxylation. Metyrapone and safrole preferentially inhibited 7-hydroxylation. Chloroquine and quinine pretreatment increased urinary excretion of CPZ and its metabolites, probably due to occupation of CPZ-binding sites rather than as a result of enzyme induction.