Two human c-onc genes are located on the long arm of chromosome 8.
- 1 December 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (24) , 7842-7846
- https://doi.org/10.1073/pnas.79.24.7842
Abstract
In situ chromosome hybridization techniques were used to map the human cellular counterparts (c-onc genes) of the transforming genes of 2 RNA tumor viruses on human meiotic pachytene and somatic metaphase chromosomes. The human c-mos gene is located on chromosome 8 at a position corresponding to band 8q22 on the somatic map. The human c-myc gene is found on chromosome 8 at position 8q24. These regions on the long arm of chromosome 8 were previously reported to be involved in specific translocations found in the M-2 subset of acute nonlymphoblastic leukemias, Burkitt lymphoma and other forms of non-Hodgkin lymphoma, and a familial abnormality that predisposes to renal cell carcinoma. Thus, translocations of the human c-mos or c-myc genes may be causally related to neoplastic transformation.This publication has 58 references indexed in Scilit:
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