Gibberellic acid by solid state fermentation: Consistent and improved yields

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Abstract
Five strains each of Gibberella fujikuroi and Fusarium monoliforme were screened to select G. fujikuroi P-3, a strain capable of giving consistent production of gibberellic acid (GA3) by solid state fermentation (SSF). The comparative production of GA3 by SSF and submerged fermentation (SmF) indicated better productivity with the former technique. The accumulation of GA3 was 1.626 times higher in the case of SSF. On the basis of available carbohydrates in the media, the percent conversions were 0.096 and 0.156 in SmF and SSF, respectively. The use of coarse wheat bran of the particle size of 0.3–0.4 cm resulted in an increase of 2.5 times in the yield of GA3. The enrichment of commercial wheat bran with soluble starch gave enhanced accumulation to an extent of 3.5 times. The relation between GA3 production and cell growth in SSF was similar to that encountered in SmF. The consistent and improved yields to a tune of 1.22 g GA3 per kilogram dry moldy bran (DMB) establish the potential and feasibility of SSF for the production of GA3 by G. fujikuroi P-3. On preliminary cost analysis, a net savings of about 60% and 50% on fermentation medium cost and the expenditure on down-stream processing, respectively, as compared to the presently employed SmF technique was evident.

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