Viral Neoplastic Transformation of Hamster Pineal Cells in vitro: Retention of Enzymatic Function
- 14 October 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 154 (3746) , 278-279
- https://doi.org/10.1126/science.154.3746.278
Abstract
Cultures of hamster pineal tissue infected with certain oncogenic DNA viruses undergo neoplastic transformation and produce tumors when injected into homologous hosts. Hydroxyindole- O -methyl transferase, an enzyme found exclusively in the pineal gland, is present in low concentrations in transformed pineal cells in vitro and in larger amounts in tumors produced by the injected cells. This enzyme is not present in several nonpineal tissues similarly transformed.This publication has 4 references indexed in Scilit:
- In vitro neoplastic transformation of newborn hamster salivary-gland tissue by oncogenic DNA virusesCancer, 1966
- Control of Hydroxyindole O-Methyltransferase Activity in the Rat Pineal Gland by Environmental LightingJournal of Biological Chemistry, 1965
- INDUCTION BY ADENOVIRUS TYPE 7 OF TUMORS IN HAMSTERS HAVING THE ANTIGENIC CHARACTERISTICS OF SV40 VIRUSProceedings of the National Academy of Sciences, 1964
- Melatonin Synthesis in the Pineal Gland: Control by LightScience, 1963