Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice.

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Abstract
Background —We tested the hypothesis that apolipoprotein (apo)E-deficient (apoE−/−) mice with targeted disruption of the intercellular adhesion molecule-1 ( ICAM-1 ) or P-selectin gene (apoE−/− ICAM-1−/− or apoE−/− P-selectin−/− mice, respectively) are protected from neointima formation after arterial injury through inhibition of monocyte trafficking to sites of endothelial denudation. Methods and Results —ApoE−/−, apoE−/− ICAM-1−/−, or apoE−/− P-selectin−/− mice were fed an atherogenic Western diet for 5 weeks and underwent wire denudation of the left common carotid artery after 1 week of feeding. The absence of P-selectin in apoE−/− mice inhibited neointima formation by 94% ( P Conclusions —These findings demonstrate that the complete absence of P-selectin, but not ICAM-1, markedly reduces plaque area and suggest that P-selectin is critical for monocyte recruitment to sites of neointima formation after arterial injury.

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