GENETIC CONTROL OF ALDEHYDE OXIDASE ACTIVITY AND CROSS-REACTING-MATERIAL INDROSOPHILA MELANOGASTER

1 December 1978

journal article
research article
Published by Canadian Science Publishing in Canadian Journal of Genetics and Cytology

Vol. 20 (4) , 489-497
https://doi.org/10.1139/g78-057

Abstract

Four different genes are known to affect aldehyde oxidase activity (AO) in Drosophila melanogaster. Mutants at each of these loci eliminate AO activity and simultaneously eliminate detectable AO-crossing reacting material (AO-CRM) even though only one is the structural gene for AO (Aldoxⁿ). The other three genes (cin¹, lxd and mal) coordinately "control" the levels of activity of AO and two related enzymes, xanthine dehydrogenase (XDH) and pyridoxal oxidase (PO). Contrary to their effects on AO-CRM, neither of these three mutants eliminate XDH-CRM. A model of interaction of these enzymes and genes controlling their activities is discussed.

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