Influence of pH on the Effect of Hexamethylenetetramine on the Growth of Ehrlich Ascites Tumors

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Abstract
Inhibition of the growth of Ehrlich tumors by i. p. injection of hexamine increased as the pH of the solution was decreased from 7.4 to 6. Survival of the mice was correspondingly prolonged. Median survivals were 16.5, 23, and 25 days for mice given 5 daily injections of 50 ml/kg body weight of 0.8 m hexamine in 0.3 m glucose at pHs of 7.4, 6.4, and 6.0, respectively, beginning the day after tumor inoculation. Median survivals were 16.5 and 28.5 days after a single injection of 400 ml/kg of 0.06 M hexamine at pHs of 7 and 5, respectively, while similar solutions at pHs 7 and 5 without hexamine gave medians of 15.5 and 21.5 days, respectively. In vitro at pH 6.4 and 37°C some ascites cells survived in 0.8 m hexamine for 40 min, but none for 65 min; survival was measured by ability to produce tumors. Glucose had an additional small deleterious effect.

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