Cytotoxicity and mutagenicity of cis platin assayed in Neurospora

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Abstract
A Neurospora spheroplast assay was used to study the cytotoxicity and mutagenicity of cis platin (cis dichlorodiammine platinum II) in a eukaryote. Mutagenicity was measured by using reversion of several alleles of the am (NH3 assimilatory glutamate dehydrogenase) gene. A mutation (uvs-2) that disables a DNA repair pathway in Neurospora resulted in reduced sensitivity to and elimination of mutability by cis platin. The implications for other eukaryotic systems (including human cells) are discussed.

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