SOME EFFECTS OF VERATRINE UPON CIRCULATED MAMMALIAN NERVES

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Abstract
The responses of circulated cat''s peroneal nerves were recorded after intra-arterial injs. of veratrine. Veratrine has inconsistent effects on the demarcation potential. It decreases the conduction velocity. It causes repetitive discharges in response to brief single stimuli. It increases the negative after potential. It results in a decrease of spike potential magnitude. It elicits alternation of responses at certain frequencies of stimulation. It first augments and later depresses the resting electrical excitability. It alters the normal relationship between the thresholds for make and break stimulation by direct current pulses. Large doses reversibly abolish all responses. A broad correlation was found among negative afterpotential, repetition, supernormality and decrease of spike potential amplitude; this correlation had many exceptions. Each of these features could vary independently.

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