Synthesis and antimicrobial evaluation of substituted 5,6-dihydro-5-nitrouracils
- 1 August 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (8) , 1072-1074
- https://doi.org/10.1021/jm00230a020
Abstract
Reaction of 5-nitrouracil derivatives with sodium borohydride in methanol-water, followed by neutralizaiton of the product with acid, produced 5,6-dihydro-5-nitrouracil, 5,6-dihydro-6-methyl-5-nitrouracil, 5,6-dihydro-5-nitro-1-(4-nitrophenyl)uracil and 5,6-dihydro-5-nitro-1-(.beta.-D-ribofuranuronic acid ethyl ester)uracil. In assays for antimicrobial activity using strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Trichophyton mentagrophytes, significant inhibition of growth was not found.This publication has 1 reference indexed in Scilit:
- Chemical Inhibition of Cell Division of Escherichia coli by Diazo Compounds and Antagonism by TyrosineExperimental Biology and Medicine, 1954