Dose Fractionation and Hepatocyte Clonogens: α/β ≃ 1-2 Gy, and β Decreases with Increasing Delay before Assay
- 1 January 1988
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 113 (1) , 51-57
- https://doi.org/10.2307/3577179
Abstract
The sensitivity to X-ray dose fractionation was assessed for hepatocytes forming colonies in fat pads in mice. When the cells were assayed 1 day after the last irradiation the .alpha./.beta. ratio was 1.0-1.6 depending on the method of analysis. The .alpha./.beta. ratio describing the shape of the single-dose survival curve was much higher, and it did not predict the response to fractionation. When the assay was delayed for 10 months after the fractionated irradiation, the .alpha./.beta. ratio was 1.9-2.1, and the .beta. component showed the greatest change with time. It is concluded that hepatocytes respond to dose fractionation in a manner expected of a late-responding tissue, even when the cells are assayed as early as 1 day after the last dose.This publication has 3 references indexed in Scilit:
- Long-Term Repair in Vivo of Colony-Forming Ability and Chromosomal Injury in X-Irradiated Mouse HepatocytesRadiation Research, 1988
- Direct Analysis of Quantal Radiation Response DataInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1986
- Differential persistence of chromosomal damage induced in resting rat-liver cells by X-rays and 4.2-MeV neutronsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1982