The evaluation of a live salmonella vaccine in mice and chickens

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Abstract
SUMMARY: Mice vaccinated with a live attenuated strain ofSalmonella dublinwere protected against heavy challenge infections ofS. dublin, S. typhimurium, S. choleraesuisandS. anatum. Oral and subcutaneous vaccination were equally effective. When day-old chicks were orally vaccinated and subsequently challenged withS. typhimurium, the growth of the challenge organism was considerably reduced or eliminated from the livers of the vaccinated chicks whereas most of the non-vaccinated were heavily infected. Field trials with vaccinated day-old chicks showed that they suffered no setbacks in growth, stress, loss of appetite or adverse side effects.