An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids.
- 31 December 1984
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 33 (2) , 572-582
- https://doi.org/10.1248/cpb.33.572
Abstract
Acetyl glyceryl ether phosphorylcholines (platelet-activating factors; PAF), their enantiomers and their analogs were efficiently synthesized in a stereochemically unambiguous manner starting from D- and L-tartaric acids as chiral synthons. The enantiomer of C16-PAF (S-configuration) showed far less activity than the natural PAF (R-configuration), and the N-methylpiperidine and N-methylpyrrolidine analogs possessed much higher activity than natural C16-PAF.This publication has 10 references indexed in Scilit:
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