A Computer Program to Determine Diagnostic Decision Thresholds and Likelihood Ratios Illustrated with Aspartate Aminotransferase Activities after a Myocardial Infarction

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Abstract
We describe an enhancement of our earlier computer program which allows calculation of decision thresholds, sensitivity and specificity, and likelihood ratios of negative and positive test results for any chosen value of sensitivity or specificity. The program will also plot continuous receiver operating characteristic and decision level curves which permit examination of the contours created by using all the available data. We illustrate the value of these routines by showing that the sensitivity and specificity of serum aspartate aminotransferase changes during the course of a myocardial infarction.