Micafungin Enhances Neutrophil Fungicidal Functions against Candida Pseudohyphae
- 1 July 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (7) , 2730-2
- https://doi.org/10.1128/aac.48.7.2730-2732.2004
Abstract
We evaluated the effect of the combination of micafungin and polymorphonuclear leukocytes (PMN) against hyphae of Candida albicans and Candida dubliniensis . Micafungin enhanced the PMN oxidative burst dose dependently. The combination was synergistic ( C. albicans ) or additive ( C. dubliniensis ); when PMN were pretreated with granulocyte-macrophage colony-stimulating factor, the combination was more effective.Keywords
This publication has 10 references indexed in Scilit:
- Comparison of the epidemiology, drug resistance mechanisms, and virulence of andFEMS Yeast Research, 2004
- Human Phagocytic Cell Responses toScedosporium apiospermum(Pseudallescheria boydii): Variable Susceptibility to Oxidative InjuryInfection and Immunity, 2003
- Attenuation of Itraconazole Fungicidal Activity following Preexposure of Aspergillus fumigatus to FluconazoleAntimicrobial Agents and Chemotherapy, 2003
- Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulenceMicrobiology, 2002
- Antifungal Triazoles and Polymorphonuclear Leukocytes Synergize To Cause Increased Hyphal Damage toScedosporium prolificansandScedosporium apiospermumAntimicrobial Agents and Chemotherapy, 2002
- Complete glycosylphosphatidylinositol anchors are required in Candida albicans for full morphogenesis, virulence and resistance to macrophagesMolecular Microbiology, 2002
- Aspergillus Vertebral Osteomyelitis in a Child with a Primary Monocyte Killing Defect: Response to GM-CSF TherapyJournal of Infection, 2000
- Clinical and laboratory work-up of patients with neutrophil shortage or dysfunctionJournal of Immunological Methods, 1999
- Effect of Fluconazole on Human Polymorphonuclear Leucocyte Functions ex vivo against Candida albicansChemotherapy, 1999
- Comparison of Interferon‐γ, Granulocyte Colony‐Stimulating Factor, and Granulocyte‐Macrophage Colony‐Stimulating Factor for Priming Leukocyte‐Mediated Hyphal Damage of Opportunistic Fungal PathogensThe Journal of Infectious Diseases, 1999