The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.
Open Access
- 1 February 1985
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 134 (2) , 663-665
- https://doi.org/10.4049/jimmunol.134.2.663
Abstract
A monoclonal antibody to the antigen-receptor on the T cell line Jurkat induces substantial increases in [Ca++]i. Ca++ ionophores can substitute for this antibody in activation by increasing [Ca++]i to levels comparable with those seen with the antigen-receptor antibody. Stimulation with either the antigen-receptor antibody or a Ca++ ionophore leads to the appearance of the same phosphoproteins. These results suggest that the antigen-receptor initiates T cell activation by increasing [Ca++]i.Keywords
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