The Treatment of Advanced Carcinoma of the Bladder with Combination Chemotherapy

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Abstract
Thirty patients with advanced [stage] T4 transitional cell carcinoma of the bladder were treated in a prospective randomized trial with combination chemotherapy. Sixteen patients received cyclophosphamide, doxorubicin (adriamycin) and 5-fluorouracil; 14 patients received methotrexate, doxorubicin and 5-fluorouracil with folinic acid rescue. There were no complete or partial responses to either regime; there was progress of the disease in all patients. The 2 regimes were relatively nontoxic but failed to alter the natural course of the disease.