Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human.
- 1 August 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 8 (8) , 712-721
- https://doi.org/10.1161/01.hyp.8.8.712
Abstract
Specific, high affinity atrial natriuretic factor (ANF) binding sites were identified and localized by autoradiographic techniques in peripheral tissues of the guinea pig, rat, and human. In the guinea pig kidney, high concentrations of ANF binding sites were located in the glomerular apparatus, outer medulla, and small renal arteries. Other peripheral tissues containing ANF binding sites included the zona glomerulosa of the adrenal cortex, the smooth muscle layer of the aorta and gallbladder, the lung parenchyma, the posterior lobe of the pituitary, the ciliary body of the eye, and the leptomeninges and choroid plexus of the brain. The distribution of ANF binding sites in the rat and human kidney was nearly identical to those seen in the guinea pig kidney; high concentrations were present in the glomerular apparatus, outer medulla, and small renal arteries. These results are consistent with earlier physiological and pharmacological studies that suggested that ANF plays a functional role in the regulation of extracellular fluid volume and blood pressure. There appears to be little species variation in the location and concentration of renal ANF binding sites, suggesting that, at least in the kidney, the results in experimental animals are relevant to the actions of ANF in humans. The finding that ANF binding sites were stable and present in high concentrations in human postmortem kidneys further suggests that these tissues may be amenable to testing for the involvement of ANF receptor dysfunction in diseases such as hypertension and congestive heart failure.This publication has 42 references indexed in Scilit:
- Specific Binding Sites for Atrial Natriuretic Factor in the Human KidneyNew England Journal of Medicine, 1985
- Characterization of specific receptors for atrial natriuretic factor in bovine adrenal zona glomerulosaLife Sciences, 1984
- Specific receptors for atrial natriuretic factor (ANF) in cultured vascular smooth muscle cells of rat aortaBiochemical and Biophysical Research Communications, 1984
- Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosaLife Sciences, 1984
- Effect of atrial natriuretic factor (ANF)-related peptides on aldosterone secretion by adrenal glomerulosa cells: Critical role of the intramolecular disulphide bondBiochemical and Biophysical Research Communications, 1984
- Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)Biochemical and Biophysical Research Communications, 1984
- The amino acid sequence of an atrial peptide with potent diuretic and natriuretic propertiesBiochemical and Biophysical Research Communications, 1983
- Rat atrial natriuretic factor. Purification and vasorelaxant activityBiochemical and Biophysical Research Communications, 1983
- Cardionatrin I — A novel heart peptide with potent diuretic and natriuretic propertiesLife Sciences, 1983
- A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in ratsLife Sciences, 1981