Infantile and Adult-Onset Metachromatic Leukodystrophy

Publisher Website
Google Scholar
Abstract
IN certain sphingolipidoses, the age at onset of the disease correlates with the amount of detectable activity of the disease-related enzymes. Brady1 has previously shown an inverse correlation between the amount of residual enzyme activity and the rate of progression of clinical symptoms in both Gaucher's and Niemann-Pick disease. More recently a similar relation has been noted for the different forms of GM1 and GM2 gangliosidoses.2 , 3 The occurrence of both early and late onset variants of sulfatide lipidosis or metachromatic leukodystrophy (MLD) after periods of apparently normal development has been explained theoretically in a similar manner.4 MLD is . . .

This publication has 15 references indexed in Scilit: