Assignment of the gene for β-spectrin (SPTB) to chromosome 14q23→q24.2 by in situ hybridization
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 53 (4) , 232-233
- https://doi.org/10.1159/000132939
Abstract
Type I hereditary spherocytosis results from a molecular defect in the β-polypeptide of the erythrocyte cytoskeletal protein spectrin. Using a cDNA probe, we had previously assigned the gene for human erythrocyte β-spectrin (SPTB) to chromosome 14 based upon analysis of its segregation in panels of human × rodent somatic cell hybrids (Winkelmann et al., 1988). Here we report the regional localization of this gene by in situ hybridization to 14q23→q24.2.This publication has 1 reference indexed in Scilit:
- Spectrin beta-chain variant associated with hereditary elliptocytosis.Journal of Clinical Investigation, 1982