Effects of chlorine dioxide on thyroid function in the African green monkey and the rat
- 1 October 1986
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 19 (2) , 235-242
- https://doi.org/10.1080/15287398609530923
Abstract
In a previous study from this laboratory, chlorine dioxide (ClO 2 ) treated drinking water depressed thyroxine (T 4 ) levels in the African green monkey. The present study again demonstrated a decrease in T 4 levels in the same species after 4 wk of oral exposure. However, after 8 wk of treatment T 4 levels rebounded to above pretreatment levels, coinciding with an increase in thyroid radioiodide uptake. This T 4 rebound phenomenon and increased iodide uptake may be due to a compensatory endocrinological mechanism. In rats, T 4 levels dropped during the 8‐wk ClO 2 treatment period in a dose‐dependent manner, and no rebound effect was observed. Iodide uptake values in the rat were not affected. It appears that ClO 2 may have an effect on thyroid function in both species.This publication has 6 references indexed in Scilit:
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