The Carrier Potential of Liposomes in Biology and Medicine

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Abstract
(Second of Two Parts)Interaction of Liposomes with CellsSince the demonstration that liposomes can transport entrapped agents into cultured cells and influence intracellular catabolism10 an ever-increasing number of mammalian and other cells have been found capable of associating in vitro with liposomes of diverse lipid composition (Table 1). Depending on the cell type, uptake of liposomes is temperature dependent,56 proportional to the lipid concentration56, 90 and independent of pH (range, 6.8 to 8.7)90 and lipid composition,56 and it is more pronounced with monolamellar liposomes.91 With one exception,90 positive charge on the liposomal surface favors enhanced uptake (in the absence of . . .